Engineering in Medicine & Biology Society
The Long Island Chapter of the Engineering in Medicine and Biology Society (EMB-18) serves LI technical and business professionals in the medicine and biology fields. We promote and advance knowledge by providing lectures, seminars and reference material in related topics.
For upcoming EMB Society lectures and meetings, please
visit the calendar page.
> EMB 2007
LI Medicine & Biology
the Loop: Towards Smart Integrated Medical Systems
This lecture focuses on the Neural Stimulators, which have revolutionized the treatment of many neural disorders and explain strategies to develop smart integrated neurostimulators for pain management. The proposed approach exploits various Brain-Machine Interface technologies to acquire the neuronal state of the subject and deliver the electrical stimulation once a nociceptive signal is detected. The lessons learned from this research can be applied to a variety of disorders such as gastroparesis, Parkinsonís disease, epilepsy, and incontinence to name but a few.
Harvesting & Integrated Sensing in Implantable Devices
Implantable microsystems, like pacemakers and cochlear implants, have long been utilized in health care. With the miniaturization of sensors through the advances in the design of microelectromechanical systems (MEMS) and the increased computational power of the integrated circuits, the next generation of the implantable devices could lead to further breakthroughs in combating a wide range of medical disorders.
Device size, robustness to noise and energy efficiency are the three primary challenges for the next generation implantable microsystems. The Lecture focuses on integrated microsystems for power harvesting, neural recording and monitoring of concentrations of the neurotransmitter molecules and the challenges thereof.
Remarkable Human Ear, An Engineer's Viewpoint
Research and understanding of the human ear is presented from an engineering perspective. The human ear's three levels of AGC (automatic gain control) is covered. This AGC capability is a characteristic that is not measured or checked with conventional hearing tests.
Stimulation by Acoustic Fields
Remotely palpating tissue to provide feedback on focused ultrasound surgery (FUS), which due to natural biological variation at the tissue level is usually not performed open loop. Denaturation of protein by FUS increases the local elastic modulus. The acoustic radiation force, arising from attenuation of an ultrasound beam, provides stress, and a backscattered ultrasound signal provides an estimate of strain, highlighting denatured regions. The spatial resolution of radiation force imaging is less than the diameter of a cell. This led to the exploration of the acoustic field as a means of manipulating cells, eliciting reversible structural and functional changes.
Structural changes were tracked in vitro with optical and fluorescence microscopy. Functional changes were tracked in rat hippocampal cultures with a microelectrode array. The response of neuronal tissue to ultrasonic stimulus is similar to its response to electrical stimulus, and the ultrasonic stimulus does not appear to harm the tissue.
for 3D Display of ECG
The lecture describes automated ECG analysis, display of analysis results in 3D and a current application program for training medical personnel to understand the ECG. The application program for visual training uses 3-D vector analysis makes ECG diagnosis more intuitive and accurate for students and experienced clinicians alike. The program provides a useful means to appreciate a spatial understanding of myocardial activation, particularly the sequence by which electrical excitation spreads through both the normal and diseased myocardium.
Infusion Pump Technologies
The lecture highlights the hospital-wide infusion pump replacement project, covering the technology overview, application, design, human factors engineering principles, clinical acceptability and the overall project management. Based on the recent advancements in infusion therapies, the lecture also covers the integration of these pumps with various peripheral applications, further supporting the safe and effective healthcare environment.
Separation in low Re-flow Conditions
Dr Frame's research is on micro-fluidics in vivo and in micro-channels. Her interest lies in the two phase particulate low Re-flow. There are two applications: Oxygen delivery to the capillaries by red blood cells in vivo, and, Particle separation in a lab on a chip. There are no theories to predict particle distribution at branch points, however, her empirical data shows some insights into how the shape of the bifurcation is related to the volume flow vs. the particle flux.
Oscillatory Blood Pressure
This presentation focuses on a novel blood pressure measurement method and device, the operation of which is based on the external oscillatory perturbations. External Oscillatory Blood Pressure (EOBP) development was awarded National Instruments medical device development grant in 2008; presented in American Society of Anesthesiologist meeting in 2009 and in Society for Technology in Anesthesia meeting in 2010.
to Medical Imaging
New technologies in medical imaging are revolutionizing medical diagnostics and treatment. Radiographies with no film, CT scanners able to image a beating heart and ultrasound machines that can produce 3D images with systems of the size of a laptop are just some examples. This presentation gives an overview of these fascinating systems, with a description of the fundamental physics, the engineering and the medical applications.
Approach to Epidemiology
At the center of epidemiology is the problem of determining relationships between disease and exposure to possible causes. The relationships are complex as there are often many contributing causes and these causes usually interact with one another. Similarly, many genetic predispositions to disease are the combined effects of several genetic factors as well as their interactions with environmental factors. Thus, the analysis of a disease and its causes can be thought of as the analysis of a large complex system.
Because the data used in the analysis is usually inexact and often contains errors and also because many of the contributing factors are not known, the analysis usually relies heavily on statistics. While statistical analysis is robust and forgiving, in order to get meaningful results using it one must have a clear understanding of the possible functional forms these relationships can take, in order to check assumptions being made in interpreting statistical results. Similarly, two important causative factors may be missed if considered separately or as part of a linear function (as in regression analysis) but may reveal themselves clearly when considered as multiplicative factors of as a Boolean AND where both must be present in order for them to have an effect.
Arrhythmia Risk Using Digital Electrocardiography
The lecture focuses on research of cardiac electrical systems, including a synopsis of research and publications on the prediction and prevention of sudden cardiac death. Other topics covered include electrophysiologic effects of late percutaneous coronary interventions in acute myocardial infarction and identification of factors that predict survival benefit from ICD implantation among patients with Non-ischemic cardiomyapathy.
Design Using Simulation and Virtual Instrumentation
Virtual Instrument technology has widely been used for test, measurement and system level design. This lecture discusses an approach of using Virtual Instrumentation and applying it in conjunction with SPICE-based simulation technology to improve overall product design, development and test. A demonstration of a sensor/imaging circuit used in biomedical instrumentation, is showcased using SPICE and virtual instrumentation technology to highlight these concepts.
a Palette and Beyond: Report Generation with LabVIEW
Every automated test and control application needs some form of report generation, whether it is for ISO compliance, for internal tracking, or to convey the results in a meaningful form. The methodologies for automated report generation in LabVIEW are reviewed. Topics include standard VIs to create, print, save & perform format changes, express VIs to generate reports in Standard, DIAdem and DIAdem formats, HTML VIs to create and save HTML files, report Layout VIs and advanced VIs for special functions.